Sectie's

groep Holtman

  • People
  • Publicaties
  • Inge R. Holtman dr. Visit
    Position

    Position: Assistant Professor - Rosalind Franklin Junior Group Leader

    Research fields

    Research fields: Computational Neurobiology, (epi) genetics, Neurogenomics, Transcriptional regulation of microglia

    Ondersteuning
    Maaike Brummer Bsc
  • Selected publications

    1. Brain cell type-specific enhancer-promoter interactome maps and disease-risk association.
      Nott A, Holtman IR, Coufal NG, Schlachetzki JCM, Yu M, Hu R, Han CZ, Pena M, Xiao J, Wu Y, Keulen Z, Pasillas MP, O’Connor C, Nickl CK, Schafer ST, Shen Z, Rissman RA, Brewer JB, Gosselin D, Gonda DD, Levy ML, Rosenfeld MG, McVicker G, Gage FH, Ren B, Glass CK.
      Science. 2019 Nov 29;366(6469):1134-1139. doi: 10.1126/science.aay0793. Epub 2019 Nov 14.
      PMID: 31727856 Free PMC article.
    2. Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.
      Link VM, Duttke SH, Chun HB, Holtman IR, Westin E, Hoeksema MA, Abe Y, Skola D, Romanoski CE, Tao J, Fonseca GJ, Troutman TD, Spann NJ, Strid T, Sakai M, Yu M, Hu R, Fang R, Metzler D, Ren B, Glass CK.
      Cell. 2018 Jun 14;173(7):1796-1809.e17. doi: 10.1016/j.cell.2018.04.018. Epub 2018 May 17.
      PMID: 29779944 Free PMC article.
    3. An environment-dependent transcriptional network specifies human microglia identity.
      Gosselin D, Skola D, Coufal NG, Holtman IR, Schlachetzki JCM, Sajti E, Jaeger BN, O’Connor C, Fitzpatrick C, Pasillas MP, Pena M, Adair A, Gonda DD, Levy ML, Ransohoff RM, Gage FH, Glass CK.
      Science. 2017 Jun 23;356(6344):eaal3222. doi: 10.1126/science.aal3222. Epub 2017 May 25.
      PMID: 28546318 Free PMC article.
    4. Transcriptomic analysis of purified human cortical microglia reveals age-associated changes.
      Galatro TF, Holtman IR, Lerario AM, Vainchtein ID, Brouwer N, Sola PR, Veras MM, Pereira TF, Leite REP, Möller T, Wes PD, Sogayar MC, Laman JD, den Dunnen W, Pasqualucci CA, Oba-Shinjo SM, Boddeke EWGM, Marie SKN, Eggen BJL.
      Nat Neurosci. 2017 Aug;20(8):1162-1171. doi: 10.1038/nn.4597. Epub 2017 Jul 3.
      PMID: 28671693
    5. Transcriptional control of microglia phenotypes in health and disease.
      Holtman IR, Skola D, Glass CK.
      J Clin Invest. 2017 Sep 1;127(9):3220-3229. doi: 10.1172/JCI90604. Epub 2017 Jul 31.
      PMID: 28758903 Free PMC article. Review.
    6. Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis.
      Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ.
      Acta Neuropathol Commun. 2015 May 23;3:31. doi: 10.1186/s40478-015-0203-5.
      PMID: 26001565 Free PMC article.

      Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease.
      Holtman IR, Noback M, Bijlsma M, Duong KN, van der Geest MA, Ketelaars PT, Brouwer N, Vainchtein ID, Eggen BJ, Boddeke HW.
      Glia. 2015 Sep;63(9):1495-506. doi: 10.1002/glia.22810. Epub 2015 Mar 25.
      PMID: 25808223 Review.

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