Sectie's

Groep Coppes

Radiotherapy is involved in 75% of all cancer treatments. The dose that can be delivered to the tumor however is limited to the tolerance of the surrounding normal tissues. Therefore, the Coppes lab focusses on the effects of radiation on normal tissues.

  • People
  • Alumni
  • Research
  • Grants
  • Dissertations
  • Students
  • Links
  • Rob Coppes Prof.dr. Visit
    Position

    Projectleider

    Research fields

    Effecten van straling op normal weefsel

    Ass. professor
    In Memoriam
    Hette Faber (voormalig analist in de groep van Rob Coppes)
    Ondersteuning
    Postdoctorale onderzoekers
    Promovendus
  • Postdocs:
    Maarten Niemantsverdriet
    Sarah Pringle
    Nynke Hosper

    PhD students:
    Ghazaleh Ghodabi
    Isabelle Lombaert
    Martti Maimets
    Lalitha Nanduri
    Alena Novakova Jiresova
    Justin Smit
    Sonja van der Veen
    Erwin Wiegman

  •  

    Next to the physiological mechanism interaction within and between irradiated tissues, the lab is interested in the response of stem cells to radiation and subsequent regeneration of damaged tissues. We developed in vivo and in vitro models on purification and characterization of mice, rat and human neuronal, salivary, thyroid gland and esophagus stem/progenitor cells. Recently we developed a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic. Currently, the lab is investigating the possibly to use patient derived tissue and tumor derived organoids as a model to develop personalized medicine.

    Current projects:

    • ZonMW: Development of a 3D matrix for the culturing of adult tissue stem cells for therapeutic purposes
    • Stichting Tekke Huizinga Fonds: Adult stem cells of the murine and human thyroid gland: expansion and functionality
    • ZonMw: Transplantation of Adult Salivary Gland Stem Cells to Restore Salivary Gland Function after Radiotherapy
    • Dutch Cancer Society: Cell therapy to reduce radiation-toxicity to salivary glands
  • Selected ongoing projects/grants

    2019-2023 Project leader of Dutch Cancer Society grant (No. 12458):  “Treatment of radiation-induced hyposalivation cell therapy (STOPXERO)” (€645.000)

    2019-2023 Principle Investigator of Dutch Cancer Society grant (No. 12134):  “Preclinical testing of prophylactic treatments for radiotherapy-induced cardiopulmonary complications (AVERT)”

    2018-2022 Project leader of Dutch Cancer Society consortium grant (No. 12092):  “Increasing therapeutic window of proton therapy in brain, head and neck cancer (INTO-PROT)” (€1.700.00).

    2018-2022 Principle Investigator of Dutch Cancer Society infrastructure grant (No. 11766):  “IMage guided Proton/pArticle infrastructure for pre-Clinical sTudies (IMPACT)” with project leader S. Brandenburg (KVI-CART) (€2.800.000).

    2018 Project leader UMCG Kanker Researchfonds Grant: Modulation of cancer and normal tissue derived organoids response to cancer treatment (€10.500).

    2018-2022 Principle Investigator of Dutch Cancer Society grant (No. 11349): “ Hemodynamic changes in the cardiopulmonary circulation after thoracic radiotherapy” project leader P.van Luijk (€600.000).

    2017-2021: Principle Investigator of Dutch Cancer Society Young Investigator Grant (No. 10851) of Schelto Kruijff: “Precision Thyroid cAncer surgery with intraoperative molecular fluoRescent Guided imaging to rEduce overtreatmenT and postoperative morbidity (TARGET)

    2017-2021: Project leader of Dutch Cancer Society grant (No. 10650): “Autologous stem cell therapy for cancer treatment induced hypothyroidism” with Thera Links and John Plukker. (€520.000).

    2017-2021: WP leader and Principle Investigator EU Grant (Grant Agreement number: 755523): (MEDIRAD) “Implications of Medical Low Dose Radiation Exposure” with JA Langendijk (€800.000).

    2009-2021: Principle Investigator of ZonMw Grant (nr. 11.600.1023): “Transplantation of Adult Salivary Gland Stem Cells to Restore Salivary Gland Function after Radiotherapy” (€2.000.000).

  • Dissertations supervised by Rob P. Coppes ((co-) promotor or assessor):

    2019

    Hernandez Segura, A. (2019). Heterogeneity of Cellular Senescence and its Implications for the Development of Markers. [Groningen]: Rijksuniversiteit Groningen.

    Peng, J. (2019). Radiation-induced cellular senescence in salivary glands. [Groningen]: Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.103407924

    2018

    Nagle, P.W.K. (2018). The use of organoids in the study of radiation response and therapeutic window. . [Groningen]: Rijksuniversiteit Groningen

    2017

    Wieringa, H. (2017). Targeting the DNA damage response in cervical cancer[Groningen]: Rijksuniversiteit Groningen

    Wang, D. (2017). Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation [Groningen]: University of Groningen

    2016

    Klunder, L. J. (2016). Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis [Groningen]: Rijksuniversiteit Groningen

    Maimets, M. (2016). Potential of salivary gland stem cells in regenerative medicine[Groningen]: University of Groningen

    van der Veen, S. J. (2016). Radiation-induced cardiopulmonary dysfunction: Pathophysiology & Intervention strategies [Groningen]: Rijksuniversiteit Groningen

    Pattje, W. J. (2016). Radiosensitivity and metastasis in squamous cell carcinoma of the head and neck: a molecular approach [Groningen]: Rijksuniversiteit Groningen

    Spanjer, A. I. R. (2016). The WNT receptor Frizzled-8 in pulmonary remodelling and inflammation [Groningen]: Rijksuniversiteit Groningen

    2014

    Wiegman, E. M. (2014). Prediction and prevention of radiation induced lung toxicityGroningen: s.n.

    Nanduri, L. (2014). Salivary gland stem cells [S.l.]: [S.n.]

    2013

    Ghobadi, G. (2013). Pathophysiology of thoracic irradiation Groningen: s.n.

    Smit, J. K. (2013). Response evaluation of chemoradiotherapy in esophageal cancerGroningen: s.n.

    2000

    Coppes, M. H. (2000). Discogenic low back pain: lumbar spondylodesis revisitedGroningen: s.n.

    1997

    Coppes, R. C. (1997). Credit and market risk. An analysis of capital requirements for banking institutions

    1993

    Coppes, R. P. (1993). Modulation of noradrenergic neurotransmission by prejunctional auto- and heteroreceptors in the freely moving rat Drukkerij FEBO Enschede

    1948

    Coppes, A. H. J. (1948). Maatregelen en instellingen op het gebied der volksgezondheid in de stad van 100.000 inwoners. Groningen: s.n.

  • Student projects:

    • Radiation response of normal tissue and tumor stem cells
    • Involvement of YAP/TAS pathway in salivary gland stem cells maintenance.
    • Notch signalling in salivary gland stem cells
    • Role of GDNF in salivary gland stem cell expansion
    • Thyroid gland stem cells expansion

    Open application internship MCB section

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    • ESTRO cancer foundation movie to raise awareness of Radiotherapy benefits

      150 years Marie Curie – website

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