Our ambition is to understand the molecular mechanisms that control the intracellular dynamics of proteins, lipids and membranes in the context of the functional organization of cells, and to understand how these mechanisms contribute to health or, when disrupted, to human disease.
In this context our focus is also on rare congenital disorders caused by disrupted intracellular protein dynamics and cellular organization, which includes elucidating their pathogenesis, development of patient-specific iPSC-based cell models and lead identification for novel therapeutic strategies.
Professor, Principal Investigator
Cell Biology, Intracellular protein trafficking, cellular organization
| 1. | Unequal Effects of Myosin 5B Mutations in Liver and Intestine Determine the Clinical Presentation of Low-Gamma-Glutamyltransferase Cholestasis. van IJzendoorn SCD, Li Q, Qiu YL, Wang JS, Overeem AW. Hepatology. 2020 Oct;72(4):1461-1468. doi: 10.1002/hep.31430. PMID: 32583448 Review. No abstract available. |
| 2. | A Molecular Mechanism Underlying Genotype-Specific Intrahepatic Cholestasis Resulting From MYO5B Mutations. Overeem AW, Li Q, Qiu YL, Cartón-García F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van Ijzendoorn SCD. Hepatology. 2020 Jul;72(1):213-229. doi: 10.1002/hep.31002. Epub 2020 Apr 23. PMID: 31750554 Free PMC article. |
| 3. | Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation. Leng C, Overeem AW, Cartón-Garcia F, Li Q, Klappe K, Kuipers J, Cui Y, Zuhorn IS, Arango D, van IJzendoorn SCD. PLoS Biol. 2019 Nov 4;17(11):e3000531. doi: 10.1371/journal.pbio.3000531. eCollection 2019 Nov. PMID: 31682603 Free PMC article. |
| 4. | Pluripotent stem cell-derived bile canaliculi-forming hepatocytes to study genetic liver diseases involving hepatocyte polarity. Overeem AW, Klappe K, Parisi S, Klöters-Planchy P, Mataković L, du Teil Espina M, Drouin CA, Weiss KH, van IJzendoorn SCD. J Hepatol. 2019 Aug;71(2):344-356. doi: 10.1016/j.jhep.2019.03.031. Epub 2019 Apr 6. PMID: 30965071 |
| 5. | Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. Yeshaw WM, van der Zwaag M, Pinto F, Lahaye LL, Faber AI, Gómez-Sánchez R, Dolga AM, Poland C, Monaco AP, van IJzendoorn SC, Grzeschik NA, Velayos-Baeza A, Sibon OC. Elife. 2019 Feb 11;8:e43561. doi: 10.7554/eLife.43561. PMID: 30741634 Free PMC article. |
| 6. | MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update. Dhekne HS, Pylypenko O, Overeem AW, Zibouche M, Ferreira RJ, van der Velde KJ, Rings EHHM, Posovszky C, van der Sluijs P, Swertz MA, Houdusse A, van IJzendoorn SCD. Hum Mutat. 2018 Mar;39(3):333-344. doi: 10.1002/humu.23386. Epub 2018 Jan 17. PMID: 29266534 Free PMC article. Review. |
| 7. | The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders. Overeem AW, Posovszky C, Rings EH, Giepmans BN, van IJzendoorn SC. Dis Model Mech. 2016 Jan;9(1):1-12. doi: 10.1242/dmm.022269. PMID: 26747865 Free PMC article. Review. |
| 8. | Mechanisms of apical-basal axis orientation and epithelial lumen positioning. Overeem AW, Bryant DM, van IJzendoorn SC. Trends Cell Biol. 2015 Aug;25(8):476-85. doi: 10.1016/j.tcb.2015.04.002. Epub 2015 May 1. PMID: 25941134 Review. |
| 9. | The Intestinal Barrier in Parkinson's Disease: Current State of Knowledge. van IJzendoorn SCD, Derkinderen P. J Parkinsons Dis. 2019;9(s2):S323-S329. doi: 10.3233/JPD-191707. PMID: 31561386 Free PMC article. Review. |
| 10. | Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine. Klunder LJ, Faber KN, Dijkstra G, van IJzendoorn SCD. Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a027888. doi: 10.1101/cshperspect.a027888. PMID: 28213466 Free PMC article. Review. |
Dissertations supervised by Sven C.D. van IJzendoorn (co-) promotor or assessor):
2023
van Schaik, P., 2023, [Groningen]: University of Groningen. 275 p.
Sun, Y., 2023, [Groningen]: University of Groningen. 142 p.
Li, Q., 2023, [Groningen]: University of Groningen. 169 p.
Boertien, J., 2023, [Groningen]: University of Groningen. 177 p.
2020
de Jong, E., 2020, [Groningen]: University of Groningen. 116 p.
Research output: Thesis › Thesis fully internal (DIV)
Overeem, A. W., 2020, [Groningen]: Rijksuniversiteit Groningen. 225 p.
The roles of MYO5B in epithelial cells and the intestine: A focus on microvillus inclusion disease
Leng, C., 2020, [Groningen]: University of Groningen. 224 p.
2019
van de Peppel, I. P. (2019). Intestinal bile acid reabsorption in health and disease. [Groningen]: Rijksuniversiteit Groningen.
Cong, Y-Y. (2019). Molecular insights into viral respiratory infections. [Groningen]: University of Groningen.
Wijers, M. (2019). Sorting out cholesterol metabolism: novel insights into the mechanism of endosomal trafficking of lipoprotein receptors. [Groningen]: Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.102035320
2018
Unraveling VPS13A pathways: from Drosophila to human
Pinto, F., 2018, [Groningen]: University of Groningen. 153 p.
Rodrigues de Abreu, S. (2018). New insights into autophagy regulation using yeast Saccharomyces cerevisiae. [Groningen]: University of Groningen.
2017
Kirschbaum, M. (2017). Molecular mechanisms of platelet-mediated liver regeneration after partial hepatectomy [Groningen]: Rijksuniversiteit Groningen
2016
Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis
Klunder, L. J., 2016, [Groningen]: Rijksuniversiteit Groningen. 204 p.
Hoornweg, T. E. (2016). Breaking barriers: Early events in chikungunya and dengue virus infections [Groningen]: Rijksuniversiteit Groningen
Poppinga, W. J. (2016). Compartmentalized signaling in the lung: A-kinase anchoring proteins as novel drug targets for chronic obstructive pulmonary disease[Groningen]: University of Groningen
Fedoseienko, A. (2016). Identification of a novel multiprotein complex in cargo sorting that preserves metabolic pathways in the liver [Groningen]: University of Groningen
2014
Pathogenic mechanisms in microvillus inclusion disease
Dhekne, H. S., 2014, Groningen: s.n.. 144 p.
The polarized architecture of hepatocytes: Regulation by intrinsic and extrinsic factors
Slim, C., 2014, [S.l.]: [S.n.]. 153 p.
2011
Microvillus Inclusion Disease. Lessons about the apical plasma membrane.
Golachowska, M. R., 2011, Groningen: s.n.. 214 p.
1999
IJzendoorn, S. C. D. V. (1999). Transport and sorting of sphingolipids in polarized cells: the involvement of the sub-apical compartme
Students interested in an internship in our group are welcome to discuss possibilities.
Application form for an internship at one of the research groups of the section Medical Cell Biology of the department Biomedical Sciences of Cells and Systems
Postdocs:
Lucja Jarosz, 2012-2014
Sukhdeep Galsinh, 2013
Nai-Hua Hsiao, 2009-2011
Matsushita Masafumi Matsushita, 2010
Chris Mee, 2010
Ryuichi Ohgaki, 2009
Kati Juuti-Uusitalo, 2009-2010
Chris Mee, 2008
Kousei Ito, 2008
Tounsia Ait-Slimane, 2004
Tetsuo Nakayima, 2004
PhD students:
Leon Klunder, 2012-2016
Herschel Dhekne, 2010-2014
Christiaan Slim, 2010-2014
Magdalena Golachowska, 2007-2011
Kacper Wojtal, 2003-2007
Delphine Théard, 2002-2006
Joke van der Wouden, 2000-2004
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