Research Groups

Boddeke group

Currently, an increasing number of transcriptome data sets are published in scientific journals and in databases. Our group maintains a Glia Open Access Database (GOAD), a comprehensive tool to access and analyze glia transcriptome data of microglia, astrocytes and oligodendrocytes. The group also develops new methods for the analysis of transcriptome and epigenetic data and is involved in data analysis for many glia research projects at the section medical physiology of the UMCG department of neuroscience. In addition the group has extensive collaborations with international research groups as well as with pharmaceutical companies.

  • People
  • Publications
  • Erik Boddeke PhD Visit
    Position

    Vice Dean Research of the UMCG,

    Research fields

    microglia, epigenetics, aging, Multiple Sclerosis

    PhD students
    Visit
    Astrid Alsema MSc
    Visit
    Emma Gerrits Msc.
    • All Publications: mepa page or  pdf Selected Publications:
      1. Biber K, Möller T, Boddeke E, Prinz M. (2016)Central nervous system myeloid cells as drug targets: current status and translational challenges. Nat Rev Drug Discov.
      2. Raj DD, Moser J, van der Pol SM, van Os RP, Holtman IR, Brouwer N, Oeseburg H, Schaafsma W, Wesseling EM, den Dunnen W, Biber KP, de Vries HE, Eggen BJ, Boddeke HW (2015) Enhanced microglial pro-inflammatory response to lipopolysaccharide correlates with brain infiltration and blood-brain barrier dysregulation in a mouse model of telomere shortening. Aging Cell.
      3. Muñoz-Llancao P, Henríquez DR, Wilson C, Bodaleo F, Boddeke EW, Lezoualc'h F, Schmidt M, González-Billault C.(2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Neurosci
      4. Holtman IR, Raj DD, Miller JA, Schaafsma W, Yin Z, Brouwer N, Wes PD, Möller T, Orre M, Kamphuis W, Hol EM, Boddeke EW, Eggen BJ. (2015) Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis. Acta Neuropathol Commun.
      5. Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP. (2015) Neuroinflammation in Alzheimer's disease. Lancet Neurol.
      6. Holtman IR, Noback M, Bijlsma M, Duong KN, van der Geest MA, Ketelaars PT, Brouwer N, Vainchtein ID, Eggen BJ, Boddeke HW. (2015) Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease. Glia
      7. Raj DD, Jaarsma D, Holtman IR, Olah M, Ferreira FM, Schaafsma W, Brouwer N, Meijer MM, de Waard MC, van der Pluijm I, Brandt R, Kreft KL, Laman JD, de Haan G, Biber KP, Hoeijmakers JH, Eggen BJ, Boddeke HW. (2014) Priming of microglia in a DNA-repair deficient model of accelerated aging. Neurobiol Aging
      8. Bhat KP, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WF, Boddeke HW, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. (2013) Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. Cancer Cell
      9. Duarri A, Jezierska J, Fokkens M, Meijer M, Schelhaas HJ, den Dunnen WF, van Dijk F, Verschuuren-Bemelmans C, Hageman G, van de Vlies P, Küsters B, van de Warrenburg BP, Kremer B, Wijmenga C, Sinke RJ, Swertz MA, Kampinga HH, Boddeke E, Verbeek DS. (2012) Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19. Ann Neurol
      10. Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K. (2011) Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development Embo J.
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