Sven van IJzendoorn PhD

Sven van IJzendoorn received his Master degree at the University of Maastricht in 1995 and his PhD degree (cum laude) at the University of Groningen (laboratory of Dick Hoekstra) in 1999. With a long-term fellowship of the Human Frontier Science Program (HFSP) he performed his postdoctoral studies at the University of California San Francisco (UCSF) in the laboratory of Keith Mostov.

He then returned to the Netherlands to start his research group in the department of Cell Biology at the University Medical Center Groningen, where he is currently appointed as full professor. His research focusses on the molecular mechanisms that control the intracellular dynamics of proteins, lipids and membranes in the context of the functional organization of cells, and to understand how these mechanisms contribute to health or, when disrupted, to human diseases. In this context, his research also focusses on elucidating the pathogenesis of rare congenital disorders, develop patient-specific iPSC-based cell models and identify leads for novel therapeutic strategies.

Sven van IJzendoorn is member of the board of the Netherlands Association for the Study of the Liver (NASL), member of the advisory board of the Dutch Society for Cell Biology, member of the editorial board of ‘Tissue Barriers’, curator of the international registry of patients with microvillus inclusion disease, and program leader of the UMCG Center for Liver, Digestive & Metabolic Diseases.

• • All Publications: mepa page or overview (pdf file)
  • Selected Publications:

   

  1.	Unequal Effects of Myosin 5B Mutations in Liver and Intestine Determine the Clinical Presentation of Low-Gamma-Glutamyltransferase Cholestasis. van IJzendoorn SCD, Li Q, Qiu YL, Wang JS, Overeem AW. Hepatology. 2020 Oct;72(4):1461-1468. doi: 10.1002/hep.31430. PMID: 32583448 Review. No abstract available.
  2.	A Molecular Mechanism Underlying Genotype-Specific Intrahepatic Cholestasis Resulting From MYO5B Mutations. Overeem AW, Li Q, Qiu YL, Cartón-García F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van Ijzendoorn SCD. Hepatology. 2020 Jul;72(1):213-229. doi: 10.1002/hep.31002. Epub 2020 Apr 23. PMID: 31750554 Free PMC article.
  3.	Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation. Leng C, Overeem AW, Cartón-Garcia F, Li Q, Klappe K, Kuipers J, Cui Y, Zuhorn IS, Arango D, van IJzendoorn SCD. PLoS Biol. 2019 Nov 4;17(11):e3000531. doi: 10.1371/journal.pbio.3000531. eCollection 2019 Nov. PMID: 31682603 Free PMC article.
  4.	Pluripotent stem cell-derived bile canaliculi-forming hepatocytes to study genetic liver diseases involving hepatocyte polarity. Overeem AW, Klappe K, Parisi S, Klöters-Planchy P, Mataković L, du Teil Espina M, Drouin CA, Weiss KH, van IJzendoorn SCD. J Hepatol. 2019 Aug;71(2):344-356. doi: 10.1016/j.jhep.2019.03.031. Epub 2019 Apr 6. PMID: 30965071
  5.	Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility. Yeshaw WM, van der Zwaag M, Pinto F, Lahaye LL, Faber AI, Gómez-Sánchez R, Dolga AM, Poland C, Monaco AP, van IJzendoorn SC, Grzeschik NA, Velayos-Baeza A, Sibon OC.  Elife. 2019 Feb 11;8:e43561. doi: 10.7554/eLife.43561. PMID: 30741634 Free PMC article.
  6.	MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update. Dhekne HS, Pylypenko O, Overeem AW, Zibouche M, Ferreira RJ, van der Velde KJ, Rings EHHM, Posovszky C, van der Sluijs P, Swertz MA, Houdusse A, van IJzendoorn SCD. Hum Mutat. 2018 Mar;39(3):333-344. doi: 10.1002/humu.23386. Epub 2018 Jan 17. PMID: 29266534 Free PMC article. Review.
  7.	The role of enterocyte defects in the pathogenesis of congenital diarrheal disorders. Overeem AW, Posovszky C, Rings EH, Giepmans BN, van IJzendoorn SC. Dis Model Mech. 2016 Jan;9(1):1-12. doi: 10.1242/dmm.022269. PMID: 26747865 Free PMC article. Review.
  8.	Mechanisms of apical-basal axis orientation and epithelial lumen positioning. Overeem AW, Bryant DM, van IJzendoorn SC. Trends Cell Biol. 2015 Aug;25(8):476-85. doi: 10.1016/j.tcb.2015.04.002. Epub 2015 May 1. PMID: 25941134 Review.
  9.	The Intestinal Barrier in Parkinson's Disease: Current State of Knowledge. van IJzendoorn SCD, Derkinderen P. J Parkinsons Dis. 2019;9(s2):S323-S329. doi: 10.3233/JPD-191707. PMID: 31561386 Free PMC article. Review.
  10.	Mechanisms of Cell Polarity-Controlled Epithelial Homeostasis and Immunity in the Intestine. Klunder LJ, Faber KN, Dijkstra G, van IJzendoorn SCD. Cold Spring Harb Perspect Biol. 2017 Jul 5;9(7):a027888. doi: 10.1101/cshperspect.a027888. PMID: 28213466 Free PMC article. Review.