Research Groups

Hipp group

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  • Mark S. Hipp PhD Visit
    Position

    Group leader

    Research fields

    Under construction

    PhD students
    postdoctoral fellows
    • Publications (pdf)     Selected publications (https://orcid.org/0000-0002-0497-3016)  
      1. Klaips CL, Gropp MHM, Hipp MS, Hartl FU (2020) Sis1 potentiates the stress response to protein aggregation and elevated temperature. Nat Commun; 11(1):6271. doi: 10.1038/s41467-020-20000-x.
      2. Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS (2019) The nucleolus functions as a phase-separated protein quality control compartment. Science; 365(6451):342-347. doi: 10.1126/science.aaw9157.
      3. Hipp MS, Kasturi P, Hartl FU (2019) The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol; 20(7):421-435. doi: 10.1038/s41580-019-0101-y.
      4. Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R (2018) In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell; 172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030.
      5. Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS (2018) High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins. EMBO J; 37(3):337-350. doi: 10.15252/embj.201695841.
      6. Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS (2016) Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science; 351(6269):173-6. doi: 10.1126/science.aad2033.
      7. Hipp MS, Park SH, Hartl FU (2014) Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol;24(9):506-14. doi: 10.1016/j.tcb.2014.05.003.
      8. Ripaud L, Chumakova V, Antonin M, Hastie AR, Pinkert S, Körner R, Ruff KM, Pappu RV, Hornburg D, Mann M, Hartl FU, Hipp MS (2014) Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome. Proc Natl Acad Sci U S A; 111(51):18219-24. doi: 10.1073/pnas.1421313111.
      9. Hipp MS, Patel CN, Bersuker K, Riley BE, Kaiser SE, Shaler TA, Brandeis M, Kopito RR (2012) Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease. J Cell Biol; 196(5):573-87. doi: 10.1083/jcb.201110093.
      10. Hipp MS, Kalveram B, Raasi S, Groettrup M, Schmidtke G (2005) FAT10, a ubiquitin-independent signal for proteasomal degradation. Mol Cell Biol; 25(9):3483-91. doi: 10.1128/MCB.25.9.3483-3491.2005.
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