Position: PhD student (bio-informatics)
Research group: Promotor: Erik Boddeke and co-promoter: Bart Eggen.
Roles: Creating transcriptomic and epigenetics preprocessing pipelines and performing the bio-informatic analyses.
Contact: m.l.dubbelaar@umcg.nl
https://www.researchgate.net/profile/Marissa_Dubbelaar2
https://www.rug.nl/staff/m.l.dubbelaar/research
On-going projects:
- BRAin Interactive Sequencing Analysis Tool (BRAIN-SAT); facilitating interactive transcriptome analyses (http://brainsat.eu/).
The increase of big data enables more innovative research methods to address biological questions. BRAIN-SAT is an interactive platform that enables access to high-quality bulk and single cell RNA-Seq data. This tool enables complex transcriptomic analyses in the scientific community.
- Microglia meta-analysis: A comparative approach to profile the microglial transcriptome of multiple organisms.
A range of animal models are used in scientific research to approximate human physiological- and pathological processes. Gene expression profiling studies of microglia isolated from different species showed that these cells express similar genes and have comparable, conserved functions. This meta-analysis will take a closer look in the overlap of the human data with the species that are used most commonly as animal models to imitate the human transcriptomic profile.
