||Neurodegeneration, Proteostasis, Protein Aggregation, Quality Control
- Research Profile
- Selected Publications
Mark S. Hipp studied Biochemistry at the Eberhard-Karls-University Tübingen, and received his PhD at the University of Konstanz (2005). As a graduate student he worked on the effects of the ubiquitin-like modifier FAT10 on protein degradation in the Department of Biology, with Prof. Marcus Groettrup.
While working as a postdoctoral fellow in the laboratory of Prof. Ron Kopito at Stanford University he discovered that the inhibition of the proteasome observed in Huntington’s disease is not direct, but can only be explained by a network-wide effect of the aggregates. He further expanded this hypothesis during his time as a group leader at the Max Planck Institute of Biochemistry in the Department of Prof. F. Ulrich Hartl, where his group characterized the interactions of multiple different disease associated proteins with the cellular quality control machinery.
In 2019 Mark Hipp accepted a position at the University Medical Center Groningen, where he is continuing his investigation of the toxic effects of protein aggregates. Since 2020 he is also affiliated with the Carl von Ossietzky Universität Oldenburg.
Publications (overview pdf)
- Klaips CL, Gropp MHM, Hipp MS, Hartl FU (2020) Sis1 potentiates the stress response to protein aggregation and elevated temperature. Nat Commun; 11(1):6271. doi: 10.1038/s41467-020-20000-x.
- Frottin F, Schueder F, Tiwary S, Gupta R, Körner R, Schlichthaerle T, Cox J, Jungmann R, Hartl FU, Hipp MS (2019) The nucleolus functions as a phase-separated protein quality control compartment. Science; 365(6451):342-347. doi: 10.1126/science.aaw9157.
- Hipp MS, Kasturi P, Hartl FU (2019) The proteostasis network and its decline in ageing. Nat Rev Mol Cell Biol; 20(7):421-435. doi: 10.1038/s41580-019-0101-y.
- Guo Q, Lehmer C, Martínez-Sánchez A, Rudack T, Beck F, Hartmann H, Pérez-Berlanga M, Frottin F, Hipp MS, Hartl FU, Edbauer D, Baumeister W, Fernández-Busnadiego R (2018) In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell; 172(4):696-705.e12. doi: 10.1016/j.cell.2017.12.030.
- Vincenz-Donnelly L, Holthusen H, Körner R, Hansen EC, Presto J, Johansson J, Sawarkar R, Hartl FU, Hipp MS (2018) High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins. EMBO J; 37(3):337-350. doi: 10.15252/embj.201695841.
- Woerner AC, Frottin F, Hornburg D, Feng LR, Meissner F, Patra M, Tatzelt J, Mann M, Winklhofer KF, Hartl FU, Hipp MS (2016) Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA. Science; 351(6269):173-6. doi: 10.1126/science.aad2033.
- Hipp MS, Park SH, Hartl FU (2014) Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol;24(9):506-14. doi: 10.1016/j.tcb.2014.05.003.
- Ripaud L, Chumakova V, Antonin M, Hastie AR, Pinkert S, Körner R, Ruff KM, Pappu RV, Hornburg D, Mann M, Hartl FU, Hipp MS (2014) Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome. Proc Natl Acad Sci U S A; 111(51):18219-24. doi: 10.1073/pnas.1421313111.
- Hipp MS, Patel CN, Bersuker K, Riley BE, Kaiser SE, Shaler TA, Brandeis M, Kopito RR (2012) Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease. J Cell Biol; 196(5):573-87. doi: 10.1083/jcb.201110093.
- Hipp MS, Kalveram B, Raasi S, Groettrup M, Schmidtke G (2005) FAT10, a ubiquitin-independent signal for proteasomal degradation. Mol Cell Biol; 25(9):3483-91. doi: 10.1128/MCB.25.9.3483-3491.2005.