Baron group

• • All Publications: mepa page

  • Selected Publications:

  1. Werkman, I.L., Dubbelaar, M.L., van der Vlies, P., de Boer-Bergsma, J.J., Eggen B.J.L., and Baron, W. (2020). Transcriptional heterogeneity between primary adult grey and white matter astrocytes underlies differences in modulation of in vitro myelination. J. Neuroinflammation. 17:373.
  2. Werkman, I., Sikkema, A.H., Versluijs, J.B., Qin, J., de Boer, P., and Baron, W. (2020). TLR3 agonists induce fibronectin aggregation by activated astrocytes: a role of pro-inflammatory cytokines and fibronectin splice variants.  Rep. 10:532
  3. de Jong, C.G.H.M., Stancic, M., Pinxterhuis, T.H., van Horssen, J., van Dam, A.-M., Gabius, H.-J., and Baron, W. (2018). Galectin-4, a negative regulator of oligodendrocyte differentiation is persistently present in axons and microglia/macrophages in multiple sclerosis lesions.  Neuropathol. Exp. Neurol. 77:1024-1038.
  4. Wang, P., Gorter, R.P., de Jonge, J.C., Nazmuddin, M., Zhao, C., Amor, S., Hoekstra, D., and Baron, W. (2018), MMP7 cleaves remyelination-impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions, Glia 66:1625-1643.
  5. Lentferink, D.H., Jongsma, J.M., Werkman, I., and Baron, W. (2018), Grey matter OPCs are less mature and less sensitive to IFNg than white matter OPCs: consequences for remyelination, Sci Reps. 8:2113.
  6. Stoffels, J.M.J., Hoekstra, D., Franklin, R.J.M., Baron, W., and Zhao, C. (2015), The EIIIA domain from astrocyte-derived fibronectin mediates proliferation of oligodendrocyte progenitor cells following CNS demyelination. Glia 63, 242-256.
  7. Stoffels, J.M., de Jonge, J.C., Stancic, M., Nomden, A., van Strien, M.E., Ma, D., Sisková, Z., Maier, O., ffrench-Constant, C., Franklin, R.J., Hoekstra, D., Zhao, C., and Baron, W.(2013), Fibronectin aggregation in multiple sclerosis lesions impairs remyelination. Brain 136, 116-131.
  8. Stancic, M., Slijepcevic, D, Nomden, A., Vos, M.J., de Jonge, J.C., Sikkema, A.H., Gabius, H.J., Hoekstra, D., and Baron, W. (2012), Galectin-4, a novel neuronal regulator of myelination., Glia60, 919-935.
  9. Baron, W., Decker, L., Colognato, H., and ffrench-Constant, C. (2003), Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomains. Curr. Biol. 13, 151-155.
  10. Baron, W., Shattil, S.J., and ffrench-Constant, C. (2002), The oligodendrocyte precursor mitogen PDGF stimulates proliferation by activation of avb3 integrins. EMBO J. 21, 1957-1966.

Ongoing projects/grants (selection):

2020-2021: Out-of-the-box grant, Moves and Stichting MS Research (with Sander van Kasteren): EBV-infected B cells as essential inducers of demyelination in multiple sclerosis.

2018-2023: Program Grant Stichting MS Research (with MSCNN) : An integrative analysis of MS lesions to prepare the scene for effective remyelination therapy

2017-2021: Project grant Stichting MS Research (with Inge Zuhorn): Delivery of a novel therapeutic drug to the brain for myelin repair in multiple sclerosis

2017-2022: National Lotery ‘ VriendenLoterij grant, Stichting MS Research (with MSCNN): Establishment of an MS patient-derived iPS cell bank: towards a human MS lesion model in a dish

Dissertation supervised by W. Baron (co-promotor):

2021

Lentferink, D.H. (2021). Regional diversity in oligodendrocyte progenitor cells: implications for remyelination in grey and white matter. [Groningen]: University of Groningen

 2020

Werkman, I. (2020). Macroglia diversity and its effect on myelination [Groningen]: University of Groningen

Espitia Pinzon, N. (2020). Role of tissue Transglutaminase in glial cell processes involved in multiple sclerosis [Amsterdam]: Vrije Universiteit Amsterdam

2018

Wang, P. (2018). On the role of macrophages, microglia and the extracellular matrix in remyelination [Groningen]: University of Groningen

2018

Wang, P. (2018). On the role of macrophages, microglia and the extracellular matrix in remyelination [Groningen]: University of Groningen

2016

Bijlard, M. (2016). On the cause of multiple sclerosis: Molecular mechanisms regulating myelin biogenesis [Groningen]: Rijksuniversiteit Groningen

2014

Stoffels, J. (2014). Multiple sclerosis, remyelination and the role of fibronectin [Groningen]: University of Groningen

Ozgen, H. (2014). Myelin biogenesis: Dynamics of MBP, PLP and galactolipids [Groningen]: University of Groningen

2012 

Mirjana Stancic (2012). Galectins, (re)myelination and multiple sclerosis pathology [Groningen]: University of Groningen

2007

Bert Klunder (2007). Sorting and trafficking of proteins in oligodendrocytes during myelin membrane biogenesis) [Groningen]: University of Groningen

2006

Zuzane Siskova (2006): Extracellular matrix and (re)myelination. [Groningen]: University of Groningen

Student projects:

Students (bachelor, masters or technician school) who are interested to perform an internship in our group are welcome to apply. We have ample opportunities, and I would be happy to explain our research goals and possibilities for research projects in more detail. Minimal length is 3 months.

You can apply via this application form.

PhD students:
Zuzana Šišková (2006)
Bert Klunder (2007)
Mirjana Stancic (2012)
Josephine Stoffels (2014)
Hande Ozgen (2014)
Marjolein Bijlard (2016)
Peng Wang (2018)
Inge Werkman (2020)
Dennis Lentferink (2021)

Post-docs:
Olaf Maier
Tiemen van der Heide
Michel Vos
Erik Sikkema

Technicians:
Anita Nomden
Bojana Mikus

MS Center Noord Nederland (MSCNN)