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Nuclear poly-glutamine aggregates rupture the nuclear envelope and hinder its repair. Korsten G, Osinga M, Pelle RA, Serweta AK, Hoogenberg B, Kampinga HH, Kapitein LC. J Cell Biol. 2024 Nov 4;223(11):e202307142. doi: 10.1083/jcb.202307142.

Sparing of the heart facilitates recovery from cardiopulmonary side effects after thoracic irradiation. Wiedemann J, Paruchuru SK, den Boef LE, Brouwer U, Silljé HHW, Schouten EM, Dickinson MG, van Goethem MJ, Coppes RP, van Luijk P. Int J Radiat Oncol Biol Phys. 2024 Aug 14:S0360-3016(24)0317

The PhD student Maiara Kolbe Musskopf participated in the “Science in Shorts” competition organized by Nature portfolio. She had to explain her research in a creative way under 1 minute and her video was selected to be in the YouTube library of Nature portfolio.”

DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity. Ryder BD, Ustyantseva E, Boyer DR, Mendoza-Oliva A, Kuska MI, Wydorski PM, Macierzyńska P, Morgan N, Sawaya MR, Diamond MI, Kampinga HH, Joachimiak LA. Structure. 2024 Jun 6;32(6):662-678.e8

Children’s brain cancer research gets £5m boost to cut treatment side effects. Read more

Interplay of Proteostasis Capacity and Protein Aggregation: Implications for Cellular Function and Disease Mark S. Hipp & F. Ulrich Hartl Journal Molecular Biology, May 2024, 168615.

Conventional and novel anti-seizure medications reveal a particular role for GABAA in a North Sea progressive myoclonus Epilepsy Drosophila model Polet SS, de Koning TJ, Lambrechts RA, Tijssen MAJ, Sibon OCM, Gorter JA. Epilepsy Res. 2024 May 14;203:107380. doi: 10.1016/j.eplepsyres.2024.107380

Consortium the Institute for Chemical Neuroscience The consortium receives 23.3 million euros from the Gravity programme and from the UMCG, Prof Bart J.L. Eggen, Dr Inge R. Holtman and Dr Susanne M. Kooistra are involved. The other scientists involved in the project are: Main applicant: prof

Impaired coenzyme A homeostasis in cardiac dysfunction and benefits of boosting coenzyme A production with vitamin B5 and its derivatives in the management of heart failure. Wedman JJ, Sibon OCM, Mastantuono E, Iuso A. J Inherit Metab Dis. 2024 Apr 9. doi: 10.1002/jimd.12737.

Optimization of the Production Process of Clinical-Grade Human Salivary Gland Organoid-Derived Cell Therapy for the Treatment of Radiation-Induced Xerostomia in Head and Neck Cancer. Zanten JV, Jorritsma-Smit A, Westra H, Baanstra M, Bruin-Jellema A, Allersma D, Gareb B, Coppes RP. Pharmaceutics