Fulvio Reggiori PhD (guest appointment)

Fulvio Reggiori (1970) studied Biochemistry at University of Fribourg, Switzerland, and in 1997, he obtained his PhD in Biochemistry from the same Institution. Here, in the laboratory of Prof. Andreas Conzelmann, he has worked on the remodelling of the lipid moiety of GPI-anchored proteins and on sphingolipid biosynthesis in yeast Saccharomyces cerevisiae.

After staying one additional year in the same laboratory as a postodoctoral fellow, he moved to the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, in 1998. There, in the laboratory of Dr. Hugh Pelham, he has investigated the signals targeting integral membrane proteins into the internal vesicles of multivesicular bodies.

In 2001, he joined the laboratory of Prof. Daniel Klionsky at the Life Sciences Institute of the University of Michigan in Ann Arbor (USA). There, he started working on different aspects of the molecular mechanism of autophagy in yeast.

In 2005, Fulvio Reggiori was appointed as a tenured Assistant Professor at the Department of Cell Biology of the University Medical Center Utrecht, where he started is independent research career working on the molecular mechanism of autophagy. The laboratory interests also extended to pathogens that subvert autophagy to invade host cells. In 2011, he became an Associate professor at the same Institution.

2015-2022, Fulvio Reggiori became Professor at the Department of Cell Biology of the University Medical Center Groningen, where he is contuining his investigation on the molecular mechanism of autophagy in yeast and on the interaction between pathogens and the ATG proteins.

In May 2022 the Reggiori group moved to the Aarhus University in Denmark.

• • All Publications: mepa page or overview list pdf

  • Cong Y, Ulasli M, Schepers H, Mauthe M, Vkovski P, Kriegenburg F, Thiel V, de Haan CAM, Reggiori F (2020), Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle, J Virol, 94, e01925-19.
  • Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho H.-C, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S (2019), A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation, Science, 365, 53-60.
  • Gómez-Sánchez R, Rose J, Guimarães R, Mari M, Papinski D, Rieter E, Geerts WJ, Hardenberg R, Kraft C, Ungermann C, Reggiori F (2018), Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores, J Cell Biol, 217, 2743-2763.  (pdf)
  • Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema KJ, Coppes RP, Engedal N, Mari M, Reggiori F (2018), Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion, Autophagy, 14, 1435-1455. (pdf)
  • Sánchez-Wandelmer J, Kriegenburg F, Rohringer S, Schuschnig M, Gómez-Sánchez R, Zens B, Abreu S, Hardenberg R, Hollenstein D, Gao J, Ungermann C, Martens S, Kraft C, Reggiori F (2017), Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation, Nat Comm, 6, 295. (pdf)
  • Abreu S, Kriegenburg F, Gómez-Sánchez R, Mari M, Sánchez-Wandelmer J, Rasmussen MS, Soares Guimarães R, Zens B, Schuschnig M, Hardenberg R, Peter M, Johansen T, Kraft C, Martens S, Reggiori F (2017), Conserved Atg8-recognition sites mediate Atg4 association to autophagosomal membranes and Atg8 deconjugation, EMBO Rep, 18, 765-780. (pdf)
  • Mauthe M, Langereis M, Jung J, Zhou X, Jones A, Omta W, Tooze SA, Stork B, Paludan SR, Ahola T, Egan D, Behrends C, Mokry M, de Haan C, van Kuppeveld F, Reggiori F (2016), An siRNA screen for ATG depletion reveals the extent of unconventional functions of the autophagy proteome in virus replication, J Cell Biol, 214, 619-635. (pdf)
  • Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katon I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I (2015), Regulation of endoplasmic reticulum homeostasis by FAM134B-mediated selective autophagy, Nature, 522, 354-358. (pdf)
  • Cebollero E, van der Vaart A, Zhao M, Rieter E, Klionsky DJ, J. Helms B, Reggiori F (2012), Phosphatidylinositol-3-phosphate clearance plays a key role in autophagosome completion, Curr Biol, 22, 1545-1553. (pdf)
  • Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F*, Melia TJ, Klionsky DJ (2011), SNARE proteins are required for macroautophagy, Cell, 146, 290-302. *co-corresponding author (pdf)

   

1994 – 1997 PhD study at the Department of Biochemistry of the University of Fribourg, Switzerland (Supervisor: Prof. A. Conzelmann).

1997 – 1998 Postdoctoral fellow at the Department of Biochemistry of the University of Fribourg, Switzerland, with Prof. Andreas Conzelmann.

1998 – 2001 Postdoctoral fellow in the MRC Laboratory of Molecular Biology Cambridge, United Kingdom, with Dr. Hugh R.B. Pelham.

2001 – 2005 Postdoctoral fellow at the Life Sciences Institute and the Department of Molecular, Cellular, and Developmental Biology of the University of Michigan, Ann Arbor, United States of America, with Prof. Daniel Klionsky.

2005 – 2011 Tenured assistant professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

2011 – 2014 Associate professor at the Department of Cell Biology of the University Medical Center Utrecht, The Netherlands.

2014 – current Professor at the Department of Cell Biology of the University Medical Center Groningen, The Netherlands.

2016 – 2021 Dutch representative in the managing committee of the European Cooperation in Science and technology (COST) Transautophagy

2017 – 2021 Coordinator of the Marie Skłodowska-Curie Innovative Training Networks (ITN)  Driving next generation autophagy researchers towards translation (DRIVE)

2019– 2023 Dutch representative in the managing committee of the European Cooperation in Science and technology (COST) Innogly

1993 – 1994 CIBA-GEIGY prize for the best 1993/1994 graduation curriculum in chemistry and biochemistry at the University of Fribourg

1998 – 1999 Swiss National Science Foundation fellowship

1999 – 2001 EMBO long-term fellowship

2001 – 2002 EMBO long-term fellowship

2002 – 2004 Swiss National Science Foundation fellowship for advanced researchers

2006              VIDI award

2013              VICI award

2006 – Utrecht University High Potential grant (with Dr. Xander de Haan)

2006 – ZonMW VIDI grant

2007 – ZonMW Medium Investment grant

2007 – ALW Open Program grant

2010 – CW ECHO grant (with Prof. Bernd Helms)

2010 – NWO-DFG bilateral programme grant (with Prof. Christian Ungermann)

2011 – ALW Open Program grant

2012 – ALW Open Program grant

2013 – ZonMW VICI grant

2014 – Sinergia grant from SNSF (with prof. Matthias Peter and Maurizio Molinari)-

2015 – European Cooperation in Science and technology (COST) cooperation grant

2016 – Marie Skłodowska-Curie Cofund grant

2016 – ZonMW Medium Investment grant

2017 – Marie Skłodowska-Curie Innovative Training Networks (ITN) grant

2017 – ALW Open Program grant

2018 – ZonMW TOP grant (with Prof. Haim Kampinga and Dr. Lukas Kapitein)

2018 – ALW internalization program

Member of the Editorial Board of Autophagy since 2008.

Member of the Editorial Board of Microbial Cell since 2013.

Member of the Editorial Board of Oncotarget since 2015.

Member of the Editorial Board of the Journal of Biological Chemistry since 2016.

Member of the Editorial Board of the BBA Molecular Cell research since 2016.

Member of the Editorial Board of the Journal of International Biochemistry and Cell Biology since 2018.

Member of the Editorial Board of the Cells since 2018.

Member of the Editorial board of Frontiers in Cellular and Infection Microbiology since 2018.

Member of the management team at the Cell Microscopy Centre and Department of Cell Biology from 2005 to 2014 (UMC Utrecht)

Member of the management team of the Department of Biomedical Sciences of Cells & Systems from 2016 (UMC Groningen).

Head of the Molecular Cell Biology section of the Department of Biomedical Sciences of Cells & Systems from 2018 (UMC Groningen)

International council member and affiliate member of the NIH-funded Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, Albuquerque, USA, from 2018.

Board member of the Nordic Autophagy Society (NAS) since 2018

Member of the National Research Council (NRC) evaluating grant submitted to the Swiss National Science Foundation (SNSF) (2019-2021)