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Radiation-induced cellular senescence in salivary glands Promotor: Rob P. Coppes Co-promotor: L. Barazzuol dutch summary

North Sea progressive myoclonus epilepsy is exacerbated by heat, a phenotype primarily associated with affected glia. Lambrechts RA, Polet SS, Hernandez-Pichardo A, van Ninhuys L, Gorter JA, Grzeschik NA, de Koning-Tijssen MAJ, de Koning TJ, Sibon OCM. Neuroscience. 2019 Nov 1. pii: S0306-4522(1

Loss of MYO5B expression deregulates late endosome size which hinders mitotic spindle orientation Changsen Leng, Arend W. Overeem,  Fernando Cartón-Garcia,  Qinghong Li,  Karin Klappe,  Jeroen Kuipers,  Yingying Cui, Inge S. Zuhorn, Diego Arango, Sven C. D. van IJzendoorn. Published: Novem

4′-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN. Jeong SY, Hogarth P, Placzek A, Gregory AM, Fox R, Zhen D, Hamada J, van der Zwaag M, Lambrechts R, Jin H, Nilsen A, Cobb J, Pham T, Gray N, Ralle M, Duffy M, Schwanemann L, Rai P, Freed A

Cell-autonomous and non-cell autonomous protection of DNAJB6 in Huntington’s disease Promotores: Harm H. Kampinga & Erik W.G.M. Boddeke Details defense   English and Dutch Short Summary Stellingen

CHILDHOOD-ONSET MOVEMENT DISORDERS: mechanistic and therapeutic insights from Drosophila melanogaster Promotores: Ody C.M. Sibon and M.A.J. de Koning-Tijssen Co-promotor: T.J. de Koning Details defense Lekenpraatje Dutch Summary Stellingen

Vac8 spatially confines autophagosome formation at the vacuole. Hollenstein DM, Gómez-Sánchez R, Ciftci A, Kriegenburg F, Mari M, Torggler R, Licheva M, Reggiori F, Kraft C. J Cell Sci. 2019 Oct 24. pii: jcs.235002.  Pdf

Loss of genome maintenance capacity disrupts protein homeostasis leading to degenerative phenotypes

The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis. Cell Mol Life Sci. 2019 Oct 18. doi: 10.1007/s00018-019-03327-7 de Jong CGHM, Gabius HJ, Baron W. Pdf