Published in Nature Genetics by Holtman group

Spatial mapping of Alzheimer’s disease across genetic subtypes

New perspectives on Alzheimer’s disease: Spatial and single-cell transcriptomics are unlocking insights into the cellular and molecular mechanisms of AD. In our News & Views article for Nature Genetics Inge Holtman and Alexi Nott discuss how these approaches reveal shared and subtype-specific pathways, advancing our understanding of this complex disease. By integrating spatial transcriptomics with genetic risk data, researchers are uncovering novel insights into brain-layer- and cell-type-specific processes, sex differences, and genetic contributions to AD.

Alexi Nott & Inge R. Holtman 

Nature Genetics volume 56, pages 2592–2593 (2024)