Published in Diabetologia (cooperation with Giepmans group)
13 March 2023
|Insulin aberrant transcripts in the ‘wrong’ cells?
René van Tienhoven (PI: Bart Roep) and Maria Kracht (PI: Arnaud Zaldumbide) and coworkers, including Anouk Wolters (PI: Ben Giepmans) now present the presence of aberrant insulin transcripts in delta cells. Thus, insulin promotor activity may not always be specific for beta cells, which also impacts experimental models using ins promotor constructs to identify beta cells.