Published in Nature Reviews by Ody Sibon and Erick Strauss

07 September 2016

Published online

Coenzyme A: to make it or uptake it

Ody C.M. Sibon and Erick Strauss

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The consensus has been that intracellular coenzyme A (CoA) is obtained exclusively by de novobiosynthesis via a universal, conserved five-step pathway in the cell cytosol. However, old and new evidence suggest that cells (and some microorganisms) have several strategies to obtain CoA, with 4′-phosphopantetheine (P-PantSH; the fourth intermediate in the canonical CoA biosynthetic pathway) serving as a ‘nexus’ metabolite.

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