Thesis defense Inge Holtman and Duco Schriemer

29 June 2016


On the 6th of June 2016 Inge Holtman succesfully defended her thesis Exploring microglial functions under physiological and pathological conditions by genome-wide expression profiling before an committee of established researchers and was awarded with cum laude honors. Microglia cells are essential for brain homeostasis and play an important role in neurodegeneration and brain aging. Genes that are important for these microglia functions and activities are transcribed in RNA, which is subsequently translated into protein. With the recent advances in techniques to generate genome-wide RNA expression profiles, it has become possible to study microglia at a whole new level and to delineate the molecular pathways and mechanisms that regulate their function and activity in health and disease.

Inge continues to work as a post-doc in the lab of Chris Glass at the Department of Cellular & Molecular Medicine, School of Medicine at the University of California, San Diego, USA.

Dr. Holtman’s thesis can be found here.


On the 20th of June 2016 Duco Schriemer succesfully defended his thesis Genetics of Hirschsprung disease Rare variants, in vivo analysis and expression profiling before an committee of established researchers. Hirschsprung disease (HSCR) is characterized by the absence of neurons in the distal region of the colon. Due to the lack of neuronal innervation, the muscles in the colon are unable to relax, causing life-threatening obstipation. Duco investigated whether genes carrying de novo mutations in HSCR patients are involved in the development of the nervous system in the gut. This led to the identification of four new genes for HSCR.

Duco continues to work as a projectscientists at 20MED Therapeutics in Enschede, The Netherlands.

Dr. Schriemer’s thesis can be found here.


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