Project title: Amyloid-triggered glia response: the first step towards dementia?
Project: Alzheimer’s disease is a neurodegenerative disease and is the most common cause of dementia. Pathologically, this disease is characterized by brain atrophy with loss of synapses and neurons, and extracellular deposition of amyloid-beta and intracelluar accumulation of tau protein. Glial cells, in particular astrocytes and microglia, have a crucial role in regulating neuronal communication and synaptic transmission. it has been revealed that changes in glial cells induced by amyloid-beta can impact on synaptic transmisson. We hypothesize that the amyloid-beta-triggered glia response is a primary event resulting in dementia. In this project, we aim to elucidate the molecular and cellular mechanisms of the early changes in glial cells and synaptic regulations by them.
This project is Memorabel project funded by ZonMw. This is a collaboration research together with research groups in VU Amsterdam and UMC Utrecht. In UMC Groningen (UMCG), we perform transcriptomic analysis to elucidate the first gene expression changes that occur in glial cells at early stage of AD model mice and AD human tissues.
Promotors: prof. Bart Eggen and prof. Erik Boddeke