Group leaders
Position Assistant Professor, Principal Investigator
Research fields Ultrastructural characterization of the process of autophagy
  • Research Profile
  • Selected Publications
  • Muriel C. Mari studied Biochemistry and Cell Biology at the University of Nice Sophia-Antipolis, France. In 2002, she obtained herPhD in Cell Biology and Physiology from the same Institution, in the laboratory of Dr. Yannick Lemarchand-Brustel. The research topic was the identification and characterization of new Rab4 effectors and their function in glucose transport. In 2002, she extended her studies in this area by joining as a postdoctoral fellow the laboratory of Prof. David James at the Garvan Institute in Sydney, Australia. There, sheinvestigated the membrane association of the SNARE-regulating protein Munc18c.

    In 2003 Mari joined the Department of Cell Biology at the University Medical Center Utrecht (The Netherlands) to acquire competencies in advanced electron microscopy methods. There, as a Marie-Curie postdoctoral fellow in the laboratory of Prof. Hans Geuze, she investigated the intracellular trafficking of lysosomal enzyme receptors in mammalian cells.

    In 2006, Mari joined  the group of Prof. Fulvio Reggiori for an additional postdoctoral experience in Utrecht and started working on the molecular mechanism of autophagy using yeast as a model system.

    In 2015,  Muriel Mari was appointed as an Assistant Professor at the Department of Cell Biology of the University Medical Center Groningen. She is currently studying autophagosome biogenesis in yeast and mammalian cells at the ultrastructural level using techniques such as high-pressure freezing/freeze substitution, electron microscopy, immuno-electron microscopy, electron tomography and correlative light and electron microscopy.

    •             Selected publications
      1. Schoppe J, Mari M, Yavavli E, Auffarth K, Cabrera M, Walter S, Fröhlich F, Ungermann C. (2020). AP-3 vesicle uncoating occurs after HOPS-dependent vacuole tethering. EMBO J, 39:e105117. Pdf
      2. Chen S, Mari M, Parashar S, Liu D, Cui Y, Reggiori F, Novick PJ, Ferro-Novick S. (2020). Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. Proc Natl Acad Sci U S A, 117:18530-18539. Pdf
      3. Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho H.-C, Reggiori F, Farhan H, Brodsky JL, Ferro-Novick S, Lst1/SEC24C is required to package ER into autophagosomes for ER-phagy. Science, 365:53-60.  Pdf.
      4. Mauthe M, Orhon I, Rocchi C, Zhou X, Luhr M, Hijlkema K-J, Coppes RP, Engedal N, Mari M*, Reggiori F*. (2018), Chloroquine inhibits the autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy, 14:1435-1445. (*co-corresponding authors) pdf
      5. Eisenberg-Bord M, Mari M, Weill U, Rosenfeld-Gur E, Moldavski O, Castro I, Soni K, Harpaz N, Levine T, Futerman A, Reggiori F, Bankaitis V, Schuldiner M, and Bohnert M. (2017). Identification of seipin-linked factors that act as determinants of a lipid droplet subpopulation. J. Cell Biol, 217:269-282. pdf
      6. Zhou X, Cong Y, Veenendaal T, Klumperman J, Shi D*, Mari M* and Reggiori F*. (2017). Ultrastructural characterization of membrane rearrangements induced by porcine epidemic diarrhea virus infection. Viruses, 9:E251. (*co-corresponding authors) pdf
      7. Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I. (2015). Regulation of endoplasmic reticulum turnover by selective autophagy. Nature, 522:354-8.  pdf
      8. Mari M, Geerts WJ, Reggiori F. (2014), Immuno- and correlative light microscopy-electron tomography methods for 3D protein localization in yeast. Traffic, 15:1164-78. pdf
      9. Hönscher C, Mari M, Auffarth K, Griffith J, Cabrera M, Reggiori F,Ungermann C. (2014). Metabolic regulation of a novel vacuole-mitochondrial contact zone formed by the HOPS subunit Vps39 and the Rab7-like Ypt7. Dev. Cell, 30:86-94. pdf
      10. Mari M, Griffith J, Rieter E, Krisnappa L, Klionsky DJ, Reggiori F. (2010). An Atg9-containing compartment that functions in the early steps of autophagosome biogenesis. J Cell Biol, 190:1005-22.  pdf
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