Group leaders
Position Professor of Immune Physiology
Research fields Microglia, Immune Physiology, epigenetics, multiple sclerose, central nervous system
  • Research Profile
  • Selected Publications
  • Jon Laman obtained his Msc in Medical Biology from the Vrije Universiteit in Amsterdam (1987) and his PhD on antibody formation in HIV-1 infection from the Erasmus University in Rotterdam (1992). As a postdoctoral visiting investigator from TNO, he worked on CD40–CD40 ligand interactions in B-cell responses and in experimental autoimmune encephalomyelitis (EAE, model of multiple sclerosis-MS) with Dr Randy J. Noelle (Dartmouth, Lebanon, New Hampshire, USA). In 1997, he was recruited by the Department of Immunology of the Erasmus University Medical Centre Rotterdam to initiate the MS Centre ErasMS together with the neurologist and immunologist Prof. Rogier Q. Hintzen. In 2005, he was appointed as Full Professor in Immune Regulation. He closely collaborated with the Departments of Neurology (MS and Guillain-Barré syndrome), Rheumatology (rheumatoid arthritis) and Dermatology (psoriasis).

    Fall 2014, Prof. Laman joined the Department of Neuroscience of the University Medical Centre Groningen and the MS Centre North Netherlands (MSCNN) as a Professor of Immune Physiology. His research interests are chronic brain inflammation in aging and multiple sclerosis (MS) employing human and animal studies. Work of the group is part of the Groningen Coherent Programme on Ageing.

    He collaborates with different groups in the UMCG, the European Institute for the Biology of Ageing (ERIBA) and the Departments of Biology and Chemistry of the University of Groningen. Nationally, longstanding collaboration is with the Biomedical Primate Research Centre (BPRC) Rijswijk, as well as with the Brainbank and MS centers in Rotterdam and Amsterdam.

     

    • All Publications: mepa page Selected Publications:
      1. L Kracht, M Borggrewe, S Eskandar, N Brouwer, SM Chuva de Sousa Lopes, JD Laman, SA Scherjon, JR Prins, SM Kooistra and BJL Eggen Human fetal microglia acquire homeostatic immune sensing properties early in development. Science 369:530-537 (2020). doi: 10.1126/science.aba5906
      2. JD Laman, BA ‘t Hart, C Power and R Dziarski Bacterial peptidoglycan as a driver of chronic brain inflammation Trends Molecular Medicine 26:670-682 (2020) doi: 10.1016/j.molmed.2019.11.006
      3. YS Kap, C Bus-Spoor, N van Driel, ML Dubbelaar, C Grit, SM Kooistra, Z Fagrouch, EJ Verschoor, J Bauer, BJL Eggen, HJM Harmsen, JD Laman* and BA ’t Hart* (shared senior authors) Targeted diet modification reduces multiple sclerosis-like disease in adult marmoset monkeys from an outbred colony. Journal of Immunology 201:3229-3243. doi: 10.4049/jimmunol.1800822 (2018)
      4. L van der Fits, S Mourits, JSA Voerman, M Kant, L Boon, JD Laman, F Cornelissen, AM Mus, E Florencia, EP Prens and E Lubberts Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis Journal of Immunology 182:5836-5845 (2009)
      5. LA Boven, M van Meurs, M van Zwam, A Wierenga-Wolf, RQ Hintzen, RG Boot, JM Aerts, S Amor, EE Nieuwenhuis and JD Laman Myelin-laden macrophages are anti-inflammatory consistent with foam cells in multiple sclerosis Brain 129:517-526 (2006)
      6. L Visser, HJ de Heer, LA Boven, D van Riel, M van Meurs, M-J Melief, U Zähringer, J van Strijp, BN Lambrecht, EE Nieuwenhuis and JD Laman Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease Journal of Immunology 174:808-816 (2005)
      7. LA Boven, M van Meurs, RG Boot, A Mehta, L Boon, JM Aerts and JD Laman Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages American Journal of Clinical Pathology 122: 359-369 (2004)
      8. CW Ang, BC Jacobs and JD Laman Guillain-Barré syndrome, a true case of molecular mimicry Trends in Immunology 25:61-66 (2004)
      9. T Kuiken, RAM Fouchier, MSchutten, GF Rimmelzwaan, G van Amerongen, D van Riel, JD Laman, . T de Jong, G van Doornum, W Lim, AE Ling, PKS Chan, JS Tam, MC Zambon, R Gopal, C Drosten, S van der Werf, N Escriou, JC Manuguerra, K Stöhr, M Peiris and ADME Osterhaus Newly discovered coranavirus as the primary cause of severe acute respiratory syndrome The Lancet 362:263-270 (2003)
      10. AF de Vos, M van Meurs, HP Brok, LA Boven, RQ Hintzen, P van der Valk, R Ravid, S Rensing, L Boon, BA ’t Hart and JD Laman Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs Journal of Immunology 169:5415-5423 (2002)
      11. IA Schrijver, M van Meurs, M-J Melief, CW Ang, D Buljevac, R Ravid, MP Hazenberg and JD Laman Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis Brain 124:1544-1545 (2001)
      12. K Gerritse, JD Laman, RJ Noelle, A Aruffo, JA Ledbetter, WJA Boersma and E Claassen CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis Proceedings National Academy of Sciences USA 93:2499-2504 (1996)
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