Research Groups

Laman group

The group has a longstanding research line on multiple sclerosis (MS) and its animal models (EAE) in rodents and non-human primates. Jon Laman is an immunologist working on chronic brain inflammation in ageing and in age-related disease of the central nervous system (CNS). In collaboration, we contribute to research lines assessing how immune responses affect cognitive and psychiatric disease, such as delirium. We study a selection of interrelated topics:

  • Roles of costimulatory/coinhibitory receptors such as CD40 and VISTA, notably on microglia, in MS progression and remyelination
  • Contribution of infectious pathogens and gut microbiota in MS progression and remyelination
  • Stress granules in microglia related to MS lesion activity and repair.

The group integrates work with colleagues in the Dept. Neuroscience, including Erik Boddeke, Bart Eggen, Iris Sommer, Andre Aleman, Branislava Curcic-Blake, and Bert ‘t Hart (also at the Biomedical Primate Research Center BPRC). At UMCG, we work with Prof. Sophia de Rooij on delirium in the elderly, and with Prof. Kathrin Thedieck on stress granules.

For infectious pathogens and gut microbiota, we collaborate with the LifeLines cohort study, the Dept. Genetics (Dr. Sasha Zhernakova, Prof. Cisca Wijmenga), and the Dept. Microbiology (Dr. Hermie Harmsen, Prof. Alex Friedrich).

Our MS research is integral part of the MS Center Noord Nederland (MSCNN), with MS neurologists Dr. Thea Heersema and Dr. Jan Meilof, and Dr. Wia Baron of the Dept. Cell Biology.

The group welcomes motivated students at different levels and different programs, clinicians in training, and PhD students. The high level of teaching and training we provide is evidenced by the subsequent career steps of our alumni in research, the clinic, and industry positions.

  • Publications
  • Alumni
    • All Publications: mepa page Selected Publications:
      1. L Kracht, M Borggrewe, S Eskandar, N Brouwer, SM Chuva de Sousa Lopes, JD Laman, SA Scherjon, JR Prins, SM Kooistra and BJL Eggen Human fetal microglia acquire homeostatic immune sensing properties early in development. Science 369:530-537 (2020). doi: 10.1126/science.aba5906
      2. JD Laman, BA ‘t Hart, C Power and R Dziarski Bacterial peptidoglycan as a driver of chronic brain inflammation Trends Molecular Medicine 26:670-682 (2020) doi: 10.1016/j.molmed.2019.11.006
      3. YS Kap, C Bus-Spoor, N van Driel, ML Dubbelaar, C Grit, SM Kooistra, Z Fagrouch, EJ Verschoor, J Bauer, BJL Eggen, HJM Harmsen, JD Laman* and BA ’t Hart* (shared senior authors) Targeted diet modification reduces multiple sclerosis-like disease in adult marmoset monkeys from an outbred colony. Journal of Immunology 201:3229-3243. doi: 10.4049/jimmunol.1800822 (2018)
      4. L van der Fits, S Mourits, JSA Voerman, M Kant, L Boon, JD Laman, F Cornelissen, AM Mus, E Florencia, EP Prens and E Lubberts Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis Journal of Immunology 182:5836-5845 (2009)
      5. LA Boven, M van Meurs, M van Zwam, A Wierenga-Wolf, RQ Hintzen, RG Boot, JM Aerts, S Amor, EE Nieuwenhuis and JD Laman Myelin-laden macrophages are anti-inflammatory consistent with foam cells in multiple sclerosis Brain 129:517-526 (2006)
      6. L Visser, HJ de Heer, LA Boven, D van Riel, M van Meurs, M-J Melief, U Zähringer, J van Strijp, BN Lambrecht, EE Nieuwenhuis and JD Laman Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease Journal of Immunology 174:808-816 (2005)
      7. LA Boven, M van Meurs, RG Boot, A Mehta, L Boon, JM Aerts and JD Laman Gaucher cells demonstrate a distinct macrophage phenotype and resemble alternatively activated macrophages American Journal of Clinical Pathology 122: 359-369 (2004)
      8. CW Ang, BC Jacobs and JD Laman Guillain-Barré syndrome, a true case of molecular mimicry Trends in Immunology 25:61-66 (2004)
      9. T Kuiken, RAM Fouchier, MSchutten, GF Rimmelzwaan, G van Amerongen, D van Riel, JD Laman, . T de Jong, G van Doornum, W Lim, AE Ling, PKS Chan, JS Tam, MC Zambon, R Gopal, C Drosten, S van der Werf, N Escriou, JC Manuguerra, K Stöhr, M Peiris and ADME Osterhaus Newly discovered coranavirus as the primary cause of severe acute respiratory syndrome The Lancet 362:263-270 (2003)
      10. AF de Vos, M van Meurs, HP Brok, LA Boven, RQ Hintzen, P van der Valk, R Ravid, S Rensing, L Boon, BA ’t Hart and JD Laman Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs Journal of Immunology 169:5415-5423 (2002)
      11. IA Schrijver, M van Meurs, M-J Melief, CW Ang, D Buljevac, R Ravid, MP Hazenberg and JD Laman Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis Brain 124:1544-1545 (2001)
      12. K Gerritse, JD Laman, RJ Noelle, A Aruffo, JA Ledbetter, WJA Boersma and E Claassen CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis Proceedings National Academy of Sciences USA 93:2499-2504 (1996)
  • Former laboratory members who have established independent groups and obtained an associate or full professorships:
    Björn E. Clausen (Mainz),
    Rudi W. Hendriks,
    Bart C. Jacobs and
    Erik Lubberts (Rotterdam)

    Former postdoctoral investigators (in reverse chronological order): Marvin van Luijn,
    Evert Verbraak and
    Leonie A. Boven

    Former PhD students (in reverse chronological order):
    Mathilde Girard-Madoux,
    Karim K. Kreft,
    S. Anwar Jagessar,
    Rinze Neuteboom,
    Hessel van der Zee,
    Yolanda S. Kap,
    Fleur E. van der Geijn,
    Emöke Ràcz,
    Maarten G. Wolf,
    Marloes van Zwam,
    Ruth G. Huizinga,
    Marieke Emonts,
    Manon Oude Nijhuis,
    Carin P.W. Geleijns,
    Lizette Visser,
    Arjen R. Companjen,
    C. Wim Ang,
    Ingrid A. Schrijver and
    Catharina B.M. Maasssen

    Current career tracks of alumni: medical specialization (rheumatology, dermatology, medical microbiology, neurology, paediatric infectiology), laboratory specialization (clinical chemistry), pharmaceutical and biotech industry (research or management, Crucell, Merck Serono) and national (postdoc positions, associate and full professorships) and international academic research positions (full professorship, postdoc positions)

Share this:
Your browser is out-of-date!

Update your browser to view this website correctly. Update my browser now