Research Groups

Bergink group

Damage to the DNA in our cells can have detrimental consequences. Luckily, most lesions are dealt with by the cellular DNA repair pathways. However, DNA repair pathways are not always accurate and, even worse, might introduce mutations (changes in the DNA code). Here the research of  the Bergink lab starts.

  • People
  • Publications
  • Research
  • Students
  • Alumni
  • Steven Bergink PhD Visit
    Position

    Principal Investigator

    Research fields

    Genome instability influencing protein quality control; Protein quality control influencing DNA repair

    PhD students
    Maiara Kolbe Musskopf Msc.
    postdoctoral fellows
      • Selected Publications:
      1. García-Huerta P, Troncoso-Escudero P, Wu D, Thiruvalluvan A, Cisternas-Olmedo M, Henríquez DR, Plate L, Chana-Cuevas P, Saquel C, Thielen P, Longo KA, Geddes BJ, Lederkremer GZ, Sharma N, Shenkman M, Naphade S, Sardi SP, Spichiger C, Richter HG, Court FA, Tshilenge KT, Ellerby LM, Wiseman RL, Gonzalez-Billault C, Bergink S, Vidal RL, Hetz C. Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates. Acta Neuropathol. 2020 Jul 8. doi: 10.1007/s00401-020-02183-1.
      2. Serlidaki D, van Waarde MAWH, Rohland L, Wentink AS, Dekker SL, Kamphuis MJ, Boertien JM, Brunsting JF, Nillegoda NB, Bukau B, Mayer MP, Kampinga HH, Bergink S. Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones. J Biol Chem. 2020 May 22;295(21):7301-7316. doi: 10.1074/jbc.RA119.012449. *corresponding author
      3. Thiruvalluvan A, Eduardo P. de Mattos EP, Brunsting JF, Bakels R, Serlidaki D, Barazzuol L, Conforti P, Fatima S, Koyuncu S, Cattaneo E, Vilchez D, Bergink S*, Boddeke EHWG*, Copray S*, Kampinga HH*. DNAJB6, a key factor in neuronal sensitivity to amyloidogenesis. Mol Cell 2020 Apr 16;78(2):346-358.e9. doi: 10.1016/j.molcel.2020.02.022. *senior author
      4. Meister-Broekema M, Freilich R, Jagadeesan C, Rauch JN, Bengoechea R, Motley WW, Kuiper EFE , Minoia M, Furtado GV, van Waarde MAWH, Bird SJ, Rebelo A, Zuchner S, Pytel P, Scherer SS, Morelli FF, Carra S, Weihl CC, Bergink S*, Gestwicki JE*, and Kampinga HH* Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nat commun 17;9(1)5342 (2018) doi: 10.1038/s41467-018-07718-5. *senior author
      5. Kuiper EFE, de Mattos EP, Jardim LB, Kampinga HH, and Bergink S. Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch. Front Neurosci 11, 145. (2017) doi: 10.3389/fnins.2017.00145. corresponding author
      6. Kakkar V, Månsson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen J, Linse S, van de Sluis B, Emanuelsson C, and Kampinga HH. The S/T-rich motif in the DNAJB6 chaperone delays polyglutamine aggregation and the onset of disease in a mouse model. Mol Cell 62, 272-283  (2016) doi: 10.1016/j.molcel.2016.03.017.
      7. Kampinga HH, Bergink S. Heat shock proteins as potential targets for protective strategies in neurodegeneration. Lancet Neurol 15(7) 748-59 (2016) doi: 10.1016/S1474-4422(16)00099-5.
      8. Bergink S, Ammon T, Kern M, Schermelleh L, Leonhardt H, and Jentsch S. Role of Cdc48 (p97) as a SUMO-targeted segregase curbing Rad51-Rad52 interaction. Nat Cell Biol 15, 526-532, (2013) doi: 10.1038/ncb2729.
      9. Bergink S and Jentsch S. Principles of ubiquitin and SUMO modifications in DNA repair. Nature 458, 461-467, (2009) doi: 10.1038/nature07963.
      10. Bergink S, Salomons FA, Hoogstraten D, Groothuis TA, de Waard H, Wu J, Yuan L, Citterio E, Houtsmuller AB, Neefjes J, Hoeijmakers JH, Vermeulen W, and Dantuma NP. DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A.  Genes Dev 20, 1343-1352, (2006)
  • As DNA encodes for proteins, these mutations might lead to differences in proteins. Apart from these changes in protein composition, the expression level of proteins might also change, when for example the regulatory elements surrounding a gene are affected. Currently it is unclear to what extent DNA damage impacts our proteomes, or how the cellular pathways that deal with protein stress (the protein quality control pathways) respond to DNA damage. My lab investigates this link between genome instability and protein quality control.

    My lab investigates this link between genome instability and protein quality control.

  • Student projects:

    HBO students need to have an average of  7,5

    You can apply via this application form.

  • Master students:
    Koen Bokern
    Suzanne L. Dekker
    Babet Halberstadt
    Anneke Miedema (together with P. Dijkers)
    Chandhuru Jagadeesan
    Wouter Huiting (together with E. Nollen)
    Joris van der Lienden
    Femmy Stempels

    Scientific co-workers:
    Chandhuru Jagadeesan

    Technicians:
    Renske Veenendaal

    Technician trainees:
    Fleur Broek
    Jean Paul Entingh
    Elvan Sonmez

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