Stand Up to Cancer and Cancer Research UK grant to Lara Barazzuol group (together with the University of Manchester and St. Jude Children’s Research Hospital)

12 November 2020
BRAINatomy, an atlas of brain damage after radiotherapy

UMCG is participating in an international study into the effect of radiotherapy on the development of the brains of young children. The study is funded by Stand Up to Cancer (SU2C) and Cancer Research UK (CRUK)  with $1 million. The aim of this international study is to develop a brain ‘atlas’ to locate regions of the brain that are most sensitive to damage by radiotherapy.

The University of Manchester team, led by Martin McCabe, and the St. Jude Children’s Research Hospital team, led by Thomas Merchant, will analyse a large cohort of paediatric patients treated with conventional X-ray radiotherapy and proton beam radiotherapy. While the UMCG team, led by Lara Barazzuol, will examine how radiotherapy with X-rays and protons damages the developing brain from the brain’s structural level down to the single-cell level, and will confirm the findings from the atlas developed using patient data in animal models.

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