Radiotherapy is involved in 75% of all cancer treatments. The dose that can be delivered to the tumor however is limited to the tolerance of the surrounding normal tissues. Therefore, the Coppes lab focusses on the effects of radiation on normal tissues.
Effects of radiation on normal tissues
Next to the physiological mechanism interaction within and between irradiated tissues, the lab is interested in the response of stem cells to radiation and subsequent regeneration of damaged tissues. We developed in vivo and in vitro models on purification and characterization of mice, rat and human neuronal, salivary, thyroid gland and esophagus stem/progenitor cells. Recently we developed a protocol for adult stem cell therapy for radiation-induced hyposalivation and consequential xerostomia, which is now being translated to the clinic. Currently, the lab is investigating the possibly to use patient derived tissue and tumor derived organoids as a model to develop personalized medicine.
Selected ongoing projects/grants
2019-2023 Project leader of Dutch Cancer Society grant (No. 12458): “Treatment of radiation-induced hyposalivation cell therapy (STOPXERO)” (€645.000)
2019-2023 Principle Investigator of Dutch Cancer Society grant (No. 12134): “Preclinical testing of prophylactic treatments for radiotherapy-induced cardiopulmonary complications (AVERT)”
2018-2022 Project leader of Dutch Cancer Society consortium grant (No. 12092): “Increasing therapeutic window of proton therapy in brain, head and neck cancer (INTO-PROT)” (€1.700.00).
2018-2022 Principle Investigator of Dutch Cancer Society infrastructure grant (No. 11766): “IMage guided Proton/pArticle infrastructure for pre-Clinical sTudies (IMPACT)” with project leader S. Brandenburg (KVI-CART) (€2.800.000).
2018 Project leader UMCG Kanker Researchfonds Grant: Modulation of cancer and normal tissue derived organoids response to cancer treatment (€10.500).
2018-2022 Principle Investigator of Dutch Cancer Society grant (No. 11349): “ Hemodynamic changes in the cardiopulmonary circulation after thoracic radiotherapy” project leader P.van Luijk (€600.000).
2017-2021: Principle Investigator of Dutch Cancer Society Young Investigator Grant (No. 10851) of Schelto Kruijff: “Precision Thyroid cAncer surgery with intraoperative molecular fluoRescent Guided imaging to rEduce overtreatmenT and postoperative morbidity (TARGET)
2017-2021: Project leader of Dutch Cancer Society grant (No. 10650): “Autologous stem cell therapy for cancer treatment induced hypothyroidism” with Thera Links and John Plukker. (€520.000).
2017-2021: WP leader and Principle Investigator EU Grant (Grant Agreement number: 755523): (MEDIRAD) “Implications of Medical Low Dose Radiation Exposure” with JA Langendijk (€800.000).
2009-2021: Principle Investigator of ZonMw Grant (nr. 11.600.1023): “Transplantation of Adult Salivary Gland Stem Cells to Restore Salivary Gland Function after Radiotherapy” (€2.000.000).
Hernandez Segura, A. (2019). Heterogeneity of Cellular Senescence and its Implications for the Development of Markers. [Groningen]: Rijksuniversiteit Groningen.
Nagle, P.W.K. (2018). The use of organoids in the study of radiation response and therapeutic window. . [Groningen]: Rijksuniversiteit Groningen
Wieringa, H. (2017). Targeting the DNA damage response in cervical cancer[Groningen]: Rijksuniversiteit Groningen
Wang, D. (2017). Towards a more personalized approach in the treatment of esophageal cancer focusing on predictive factors in response to chemoradiation [Groningen]: University of Groningen
Klunder, L. J. (2016). Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis [Groningen]: Rijksuniversiteit Groningen
Maimets, M. (2016). Potential of salivary gland stem cells in regenerative medicine[Groningen]: University of Groningen
van der Veen, S. J. (2016). Radiation-induced cardiopulmonary dysfunction: Pathophysiology & Intervention strategies [Groningen]: Rijksuniversiteit Groningen
Pattje, W. J. (2016). Radiosensitivity and metastasis in squamous cell carcinoma of the head and neck: a molecular approach [Groningen]: Rijksuniversiteit Groningen
Spanjer, A. I. R. (2016). The WNT receptor Frizzled-8 in pulmonary remodelling and inflammation [Groningen]: Rijksuniversiteit Groningen
Wiegman, E. M. (2014). Prediction and prevention of radiation induced lung toxicityGroningen: s.n.
Nanduri, L. (2014). Salivary gland stem cells [S.l.]: [S.n.]
Ghobadi, G. (2013). Pathophysiology of thoracic irradiation Groningen: s.n.
Smit, J. K. (2013). Response evaluation of chemoradiotherapy in esophageal cancerGroningen: s.n.
Coppes, M. H. (2000). Discogenic low back pain: lumbar spondylodesis revisitedGroningen: s.n.
Coppes, R. C. (1997). Credit and market risk. An analysis of capital requirements for banking institutions
Coppes, R. P. (1993). Modulation of noradrenergic neurotransmission by prejunctional auto- and heteroreceptors in the freely moving rat Drukkerij FEBO Enschede
Coppes, A. H. J. (1948). Maatregelen en instellingen op het gebied der volksgezondheid in de stad van 100.000 inwoners. Groningen: s.n.
Alena Novakova Jiresova
Sonja van der Veen